Place it as the final punchline after a long ramble, with a reaction sound first to set up the interruption. Follow it with Bruh for a deadpan beat, then Emotional Damage when Jerry keeps going anyway.
About this sound
This nine-second clip is a high-pitched shut-down aimed at Jerry, telling him to be quiet because nobody cares, delivered in an Elmo-style voice. It feels blunt, fed-up and gleefully rude, the kind of line that lands when someone has talked far too long. The uploader credits it to Elmo.