Place it at the very end of an argument clip, after the other person's claim has played in full, so it works as the closing punchline. Pair it with Nope Meme Sound before the claim to set up the refusal, then follow the shutdown with No God Please No as the loser's reaction.
About this sound
This clip, under three seconds long, features Dwayne 'The Rock' Johnson delivering his WWE catchphrase 'It doesn't matter what you think' in a loud, confident voice, pausing near the end while the audience reacts. It feels bold and dismissive, turning a disagreement into a joke. The line comes from Johnson's WWE promos in the late 1990s, where he used it to shut down opponents who tried to interrupt him.