The Binding of Isaac is a dark roguelike dungeon crawler released in 2011, in which players control Isaac, a young child fleeing through a monster-filled basement. Its unsettling mix of childlike imagery and horror made its cries and baby-themed enemies memorable to players. Short clips like this one later spread through gaming soundboards and video edits, where creators reuse them outside the game as quick jump-scare and reaction sounds. It remains popular because the cry is instantly recognisable to fans and instantly startling to everyone else.