Place it immediately after the foolish statement so the insult answers it directly, then follow with Oh My God Wow for disbelief or Damn for a sharper finish, keeping the insult as the centre of the exchange.
About this sound
This is a Russian spoken insult lasting about eighteen seconds, delivered as a direct, profanity-laced call-out telling the listener they have no brains at all. It feels mocking, confrontational and deliberately rude, the kind of blunt put-down that lands hardest when aimed at a foolish statement or a clueless reply.