Place it as the reply beat after a pointless reveal builds up, not as the opener. Lead in with Sudden Suspense to raise the stakes, let this clip deliver the shutdown, then follow with a laugh track style button only if the scene needs a release.
About this sound
This clip is a spoken reaction built around the phrase who cares poh hueon, delivered as a flat brush-off in Chilean slang. Poh softens the line like a casual filler, while hueon adds a rough, matey edge. The feeling is pure indifference, funny because it shuts a topic down without anger or explanation, just total disinterest.