Place it at the end of a frustration build in an edit, after a failed attempt freezes on screen. Lead in with the No No Wait Wait button for panic, then follow with the Faaaa Meme Sound Button to stretch the collapse further.
About this sound
A 1.6-second voice clip of a man in Spanish groaning 'ya no aguanto más' in an agonized, drawn-out delivery. The line sounds exhausted and theatrically defeated, like someone finally giving up under too much pressure. It feels funny because the suffering is so exaggerated for such a short outburst.