This clip circulates online as a Spanish reaction sound rather than as a line tied to one widely documented film, show or creator, so its appeal comes from the phrase itself rather than a single famous scene. No de nuevo is a common everyday expression in Spanish, which makes it instantly understandable to Spanish-speaking viewers and easy to read even for others through tone alone. As short reaction audio spread through memes, edits and soundboards, it became a shorthand for repeated failure, and it remains useful because almost every funny mishap has a second act.