The line comes from Dumb and Dumber, the 1994 comedy film that became a long-running source of quotable dialogue for memes and soundboards. Short clips from the film circulated online as fans reused its blunt, silly humour in edits, reaction videos and gaming streams, and this particular phrase stuck because it is short, easy to recognise and easy to drop into almost any joke about medicine. Its continued use owes less to a single viral moment than to the film's lasting place in internet comedy, where familiar movie lines are recycled as instant punchlines.