Put it at the peak of a fail, after a warning cue and before the reaction shot. Start with the danger alarm to build tension, follow with the bomb warning for the setup, then let this blast close the gag and hand over to a shocked response.
About this sound
This 144-millisecond blast from Angry Birds Space packs a sharp crack and a round, cartoon boom into almost no time at all. It feels playful and punchy, more like a comic pop than a real explosion, so the impact lands fast and clears away for the joke. The effect comes from the 2012 space-themed game, where it marked explosive moments in its low-gravity levels.