Place it as the final payoff after a short tension cue, then follow it with a lighter reaction sound once the dust settles. Try Dun Dun Dun first to build suspense, then this blast, then Vine Boom for a quick second hit.
About this sound
This is a long, deep explosion sound that stretches a single booming rumble across about eight and a half seconds, with a heavy low-end swell that feels like something enormous detonating far away. It lands as tense, dramatic and slightly absurd, turning an ordinary fail or reveal into a catastrophe-sized punchline. It is presented as the blast of a nuclear explosion.