Place it at the end of a short exchange, right after someone asks where a character was, then follow it with Ceeday Huh for the reply and Oh My God Wow when the group finally understands the joke.
About this sound
This is a short Spanish voice clip of about four seconds in which someone says, in a flat, matter-of-fact tone, that they were in the bathroom on Saturday. The plain delivery makes the odd, out-of-place detail land as funny and slightly awkward, like an answer that raises more questions than it settles.