Place this clip at the very end of a reaction edit as the final verdict, after a Windows XP Error Sound Button cue signals the failure, and do not follow it with another joke line.
About this sound
This is a short voice clip of Professor Farnsworth delivering his line about not wanting to live on this planet anymore, spoken in a flat, defeated tone. It lands as resigned and darkly funny, the sound of someone giving up on humanity after hearing something hopeless. The line comes from the animated series Futurama.