Place it right after the visual reveal of the mess, then follow it with a wet fart for a double reaction that keeps the joke moving. For a gaming edit, put it before an enemy spotted callout so the complaint sets up the next threat.
About this sound
This 4-second clip features a Half-Life scientist reacting in disgust to a foul smell, his voice rising in clear, exasperated complaint. It feels awkwardly funny, like catching someone else saying exactly what everyone is thinking in a bad-smelling room. The line comes from the Half-Life games, where the scientists often voice dry, nervous observations.