Place it at the end of a failed joke or gaming clip, after the setup has played out, then follow it with a Classic Fart Sound Effect for a second payoff or a SpongeBob Fail Sound Effect to underline the fail.
About this sound
This short clip starts with a high, gasping laugh that collapses into a wet, over-the-top retch, like someone laughing until they feel ill. The uncontrolled bursts and cartoonish gag make it feel funny and gross at once, and the abrupt change from delight to disgust catches listeners by surprise. It circulates as a user-generated reaction clip rather than a line from a film, show or game.